Ultima-TB-500 5mg

TB-500 is a synthetic version of the peptide Thymosin Beta 4 (TB-500), which naturally occurs in nearly all human and animal cells. As a first-in-class drug candidate, it promotes:

    Differentiation of endothelial (blood vessel) cells
    Angiogenesis (formation of new blood vessels from existing ones) in dermal tissues
    Migration of keratinocytes
    Deposition of collagen; and
    Reduction of inflammation.

One of the key mechanisms by which TB-500 operates is through its regulation of Actin, a crucial protein involved in cell structure and movement. Actin constitutes up to 10% of the total proteins in cells, making it a significant factor in cellular genetics.

This powerful peptide belongs to a widespread family of 16 related molecules, which share a highly conserved sequence and presence in most tissues and circulating cells throughout the body. TB-500 not only interacts with actin but also inhibits actin polymerization and serves as the actin-sequestering agent in eukaryotic cells.

TB-500 was recognized as a gene that increased four to six times during the initial stages of blood vessel development and has been found to facilitate the generation of new blood vessels from existing ones. This peptide is found in wound fluid, and when delivered subcutaneously, it enhances wound healing, promotes muscle growth, and accelerates the recovery time of muscle fibers and their cells.

Another important feature of TB-500 is its ability to encourage cell migration through a specific interaction with actin within the cell cytoskeleton. Research has shown that a specific small amino acid long-actin binding domain possesses both blood cell reproduction and wound healing properties. These properties manifest through the enhanced migration of endothelial cells and keratinocytes and an increase in the production of enzymes that degrade the extracellular matrix.

Studies indicate that TB-500 is an effective, naturally occurring factor for wound repair that also has anti-inflammatory effects. Unlike other repair factors like growth factors, TB-500 facilitates the migration of endothelial and keratinocyte cells. Additionally, it does not attach to the extracellular matrix and has a very low molecular weight, allowing it to move relatively long distances within tissues.